Panicale’s main church is dedicated to Saint Michael the Archangel, the patron saint of the Lombard nation. No trace of the original building remains. In 1546 the interior was enlarged and a new roof was built on three brick support arches. Two stone cornices and a panel painting depicting the nativity, originally situated at the main altar, were retained from the Renaissance church.
The single nave church has a dais, a choir, six side chapels, and a stonework vaulted ceiling decorated with seven medallions depicting stories from the life of the Virgin.